![]() §§Fuel economy improvement is based on Synergy-branded gasoline compared to gasoline meeting minimum U.S. The Exxon Mobil Rewards+ Program Terms and Conditions apply. Your Premium Status is non-transferrable and does not preclude you from using other Exxon Mobil Rewards+ offers, unless specified. To view full Exxon Mobil Rewards+ terms, please click here. You will also be eligible for various Premium Status offers and experiences that are available to Exxon Mobil Rewards+ Premium Status members. Benefits include earning double base points (for a total of 6 points per gallon) on all Synergy Supreme+ purchases after earning and while maintaining Premium Status. In the event that Premium Status is not maintained in the following month, you have a grace period of three consecutive months starting from the end of the month in which Premium Status was last earned before your Premium Status benefits expire. You must complete three Qualifying Purchases each calendar month to maintain your Benefits. Exxon Mobil Rewards+ Premium Status Benefits (“Benefits”) begin after Premium Status is earned. You must present and use your Exxon Mobil Rewards+ card loyalty identifier prior to making a Qualifying Purchase at participating locations. A Qualifying Purchase is defined as a purchase of 8 gallons or more of Synergy Supreme+ fuel with the Exxon Mobil Rewards+ program. §Exxon Mobil Rewards+ Premium Status (“Premium Status”) is achieved by making three (3) “Qualifying Purchases” in a calendar month. Concentration and availability of our proprietary additive package may vary based on factors beyond our control. Actual benefits are based on continuous use and may vary depending on vehicle type, driving style, and gasoline previously used. Wear reduction was measured by an industry standard lubricant test. ‡‡Based on Synergy Supreme+ gas compared to gasoline meeting minimum government standards. ![]() Concentration and availability of our proprietary additive package may vary based upon factors beyond our control. ††Based on comparison of Synergy Supreme+ premium gas to gasoline that meets minimum government standards. ‡Based on comparison of Synergy Supreme+ gas compared to Synergy regular gas in port fuel injected engines.
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![]() Depreciated Template:Icon faction icons with Template:Faction tooltips.Added support for slam attack row in Template:StanceTables. ![]() Wiki updated from MediaWiki v1.33.3 to MediaWiki v1.37.2.All non-Exalted primaries, secondaries, and melees should now use Template:Advantages and Template:Disadvantages under the Characteristics section and abide by WARFRAME Wiki:Stat Comparison.Template:AbilityU10.3 horizontal infobox now match user's theming and pulls data from Module:Ability/data.All individual mission nodes now have their own article pages if readers want to query for drop table data that way.Wiki updated from MediaWiki v1.37.6 to MediaWiki v1.39.3.Added MapsExtended JS script to MediaWiki:ImportJS.See WARFRAME Wiki:Official Wiki for details. Digital Extremes partnered with Fandom to join the Official Community Partnership program, designating this wiki to be an "Official Wiki".Volunteer developers and researchers are always welcomed!Īs Digital Extremes does not actively engage with the activity on this wiki, users are encouraged to post feedback, bug reports, or suggestions to the official Warframe website and its support page. A great place to start helping is to look into our current site-wide Projects for needed edits and contributions. New editors are encouraged to take note of our Policies or contact an Administrator or Moderator for any questions regarding the wiki. The wiki is maintained by countless active players and fans from around the world and we welcome anyone to join our community, share your knowledge, and make this wiki a better place. Our purpose is to create the most complete database about the game on everything ranging from gameplay explanations, weapon statistics, combat mechanics, to the titular Warframes and the background lore of the WARFRAME universe. Welcome to the WARFRAME Wiki, a completely player-supported encyclopedia about the game WARFRAME. ![]() It exceeds its competitors in supporting some other free cloud services like Box.net, Mega, hubiC, Jottacloud, Rackspace CloudFiles, OpenStack Simple Storage, Microsoft Office 365 Groups, Microsoft SharePoint (V1, V2), Microsoft OneDrive for Business, & Sia Decentralized Cloud. It also supports multiple protocols like FTPS, SSH, & WebDAV, As it supports also the popular cloud services like Dropbox, OneDrive, GoogleDrive, & Amazon S3. File Explorer & Finder Info panel for folders/ filesģ- Duplicati (Linux, Windows, & macOS) Duplicati ĭuplicati is a free backup software that provides encrypted backups sync online to a remote server or to cloud services.Context menu integration for macOS, & Windows. ![]() It supports also multiple protocols (FTP, SFTP, WebDAV), and many cloud online servers like Dropbox, GoogleDrive, OneDrive. It uses Windows File Explorer, & macOS Finder as a file browser and sync tool for mounting, browsing, managing, & syncing with remote server or services. MountainDuck is a subset project of CyberDuck, it's also an open-source file synchronization tool, but with better integration to the operating systems it works on (Windows, macOS). Powerful macOS integration: with Finder, Keychain, Bonjour.Ģ- MountainDuck (Windows, & macOS) MountainDuck.Bookmarking manager with import/ export options.Built-in support for Dropbox, OneDrive, GoogleDrove, Amazon S3, Microsoft Azure, Backblaze B2, & RACOON.Supports: FTP, SFTP, WebDAV, OpenStack Swift.Supports many file transport protocols and online cloud services.Unfortunately, It's supporting Windows, & macOS only, with no Linux support in the current version. It supports many cloud servers like Dropbox, Google Drive, OneDrive, & S3, as well as multiple files transferring protocols, & storage options. Open-source Data backup & File Synchronization programsĬyberDuck is an open-source free(Libre/ FLOSS) server & cloud storage browser. Some of them are easy to use for novice users, others like self-hosted cloud storage will require certain technical knowledge to run it, so some may require help to install and manage. In this article, we have compiled a list of the best open source free data backup and file synchronization software programs and tools. While some of them provide free space like Dropbox, Google Drive, Box, & Sync, Many users ran out of storage space considering their usage, number of files, and size of files. Data & File backup is a major requirement for end-users, There are many cloud-based commercial services which provide cloud storage allowing users to backup their data with simple easy tools: File Synchronization clients. ![]() ![]() The staff at RWW is absolutely outstanding. I would say depending on the age and attention of your child I would plan for 1 to 2 hours. It’s just $10 per person and you can stay as long as you like. Secret Service protection "should only be granted within one year prior to the general election" except in "extraordinary, case by case circumstances.“A few weeks ago we had the pleasure of visiting Rizzo’s Wildlife World! In the past we have had two parties with them and had a blast! The first thing I liked was the cost of admission. To judge which candidates qualify the secretary is expected to consult with the Congressional Advisory Committee, which includes the Democratic and Republican leaders in both the Senate and House of Representatives. Kennedy, was assassinated while a presidential candidate."Īccording to the Secret Service website, the federal agency is tasked with protecting "major Presidential and Vice Presidential candidates," based on authorization from the Secretary of Homeland Security, currently Biden appointee Alejandro Mayorkas. "Although it is a well-known historical fact, apparently in your case it bears repeating: Mr. Kennedy Jr., who has polled more than 20% in the first five primary states, and whose net favorability rating exceeds both yours and Donald Trump's. Indeed, political assassinations pose a grave threat to democracy."Īddressing Biden directly, Kucinich continued: "It is astonishing that under such circumstances, you would deny Secret Service coverage to Robert F. A specter of violence haunts our political process. ![]() He is not the only one in danger-every person who attends a campaign event is at risk. Kucinich wrote that: "The threat level to our candidate, Robert F. Marshal." Officers arrested a man who was being held on $35,000 bail on a felony charge of carrying a concealed weapon, ABC reported. In a statement to ABC News last weekend, the LAPD said it responded to a report of a man with "a loaded gun in a shoulder holster and a badge stating he was a U.S. Kennedy's campaign is demanding he receive Secret Service protection after an armed man was arrested outside the event. ![]() speaks at a Hispanic Heritage Month event at Wilshire Ebell Theatre on Septemin Los Angeles, California. "ĭemocratic presidential candidate Robert F. He was intercepted by a private security detail before he could harm anyone, and arrested by the LAPD. The man was carrying a fully loaded weapon and was accompanied by a second individual who carried additional weapons and ammunition. Marshall sought to gain entrance to the venue where Robert F. He wrote: "This past Friday in Los Angeles, at a Hispanic Heritage event, a gunman posing as a U.S. In an open letter to Biden published on Monday, Dennis Kucinich, a former Democratic congressman and Kennedy's campaign manager, issued a call for Secret Service protection. However his coronavirus vaccine skepticism has gained Kennedy a substantial fan base on the right, with Fox News host Sean Hannity claiming he is the "best option" to defeat Biden. Kennedy has struggled to build a credible challenge to Biden who leads him by more than 50 points as Democratic voters' preferred presidential candidate, according to fivethirtyeight. Kennedy, the unorthodox Democrat's father, was murdered in June 1968. This incident took place less than two miles from where Senator Robert F. Marshal badge" and falsely claimed to be part of Kennedy's security team, according to a statement from the candidate. Police detained the man in Los Angeles by the Wilshire Ebell Theatre where Kennedy was giving an address to mark Hispanic Heritage Month. Kennedy Jr.'s campaign manager has written to President Joe Biden demanding Secret Service protection for the presidential hopeful, after an armed man was arrested on Friday night at an event where the Democratic candidate was speaking. ![]() As space and capacity were frequent issues at the old lounge, the new lounge with expanded space has enhanced the lounge experience. Overall, the new American Express Centurion Lounge at SEA Seattle-Tacoma Airport is a pleasant place to enjoy for a few hours before a flight. It is accessible by taking the elevator or staircase located in the food court in the Central Terminal.įor more information, visit the official lounge website and visit the website with details about the access policies. The new lounge is located on the mezzanine level in the Central Terminal. Cafe Check in area Buffet Dinner Buffet Buffet Seating Seating Seating Seating Seating Seating Bar area seating Co-working table Lounge Information: ![]() There are also many non-alcoholic beverages, including mocktails, iced tea, and others. Jason’s favorite Georgetown Bodhizafa is on tap and Maxine’s Gramercy Cellars Syrah is also available. They have a great selection of craft beer, wine, and cocktails. The lounge has a main bar and 2 bartenders working during peak times. One great feature is the café as it offers espresso-based handmade drinks, small bites like pastries, bowls, snacks, sandwiches, smoothies, and drinks on tap like kombucha and cold brew. A hot food buffet with various entrees, like blackened/Cajun chicken, rice, collard greens, vegetarian/vegan curry, and soups. There is a cold food buffet with a healthy juice shot, salads, veggies, cheese, and lunch meats. The buffet is curated by James Beard award nominee Chef Kristi Brown who owns “Seattle Soul” cuisine. The food options are really good and better than most lounges we’ve been to. The space where the bathrooms are is also more divided and away from the hustle and bustle of the lounge. In the old lounge, there were 3 stalls for the entire lounge: in the new lounge, there are about 4 stalls in each bathroom. One good thing about the renovations is the increased number of bathroom stalls and sinks. It feels like a trendy restaurant and bar in some spots, a peaceful and healthy café in some spots, and an upscale airport lounge in other spots. Overall, the lounge design is nice, and modern. It is much less chaotic to get food than at the old lounge. There is much more space though for the buffet and you can grab food from both sides. One minor design flaw is the buffet setup: it’s located in a high trafficked area that can make it a little awkward to grab food. One thing that is missing from the lounge is a children’s play area to minimize all the children running around and playing in the relaxation area. There are various seating options: at the bar, café style, high-top tables, restaurant-style tables, couches, recliners, workstations, and a co-working table. ![]() The lounge feels very large due to its footprint and also the tall ceilings that extend into the terminal in some parts. The new lounge is quite large and spacious: numerous sources online say it is about 3 times bigger, offers 14,000 square feet of space, and can accommodate up to 400 people. In this post, we share information about the new lounge. The new American Express Centurion Lounge at SEA Seattle-Tacoma Airport opened recently. ![]() Totally neutralizing the warmth of a wedding reception hall, for example, would feel too cold or sterile in my opinion. The aim is just to move the flash into the warmer territory, say about 4500˚K just to take some of the orange out of the ambient light when I balance for my gelled flash, but still keep the environment somewhat warm. Exactly matching my flash to the available light is not my goal. I can tape 2 or more gels to my flash if I need more correction.ģ. A full CTO (RoscoSun 85 #3401) is denser.Ģ. The 1/4 & 1/2 CTOs don't eat up more than a 1/3-1/2 stop of light, and since I usually bounce flash I need all the light I can get. Often the available light is warmer than my gelled flash, however:ġ. I leave two strips of gaffer tape on my speedlights at all times for this purpose. I'll tape them to my speedlights if I need the flash to more balance with the ambient light. When photographing events I always carry small 1/4 CTO (Rosco 3409) and 1/2 CTO (Rosco 3408) gels with me. ".speedlight.creates two different color casts to work with in post-processing." ![]() Your sliders will look something like below. In the HSL/Color panel, dial the orange down however much you need for the scene to look natural. Therefore moderate fill flash is often the best option if you're going this route.įor images with particularly warm light, you may need to dial a warm color channel back down slightly after adjusting white balance. Using a mounted speedlight flash on your camera can neutralize some of the red-orange cast of lighting, but this presents two problems. First, it makes you less conspicuous when sneaking around to take candid photos. Second, it creates two different color casts to work with in post-processing. Unfortunately, some indoor spaces have very strong warm lighting which can be difficult to process in editing later on. Incandescent lighting is warm for several reasons, none of which are important to photography (though they do look nice on skin if they're subtle). In some cases, the color cast is a mistake or a problem. Another problem is that the color from one object is reflected onto nearby objects. There are many reasons why you would have a color cast for example, because the light source has a specific hue. The cast can be across the entire range of pixel values or. A color cast is a tint that affects all or part of your image. Sixteen years later, I find myself constantly dealing with the issue of incandescent lighting casting garish color casts on much of my indoor event and real estate photography. A color cast occurs when the Red, Green, and Blue channels of an image are not properly balanced. He did what every adult does who is frustrated with technology: handed it to a youngster and asked for help. My stepfather had purchased a point-and-shoot camera and was annoyed with the over-warm color tones plaguing his indoor images. Just look at the middle of your histogram, and if the colors are skewed to one side or the other, you know you have a color cast or shift. In this way, the LAB colorspace makes it super simple to determine if you have a color cast. In my case, I don't want to remove the orange completely because I think it adds a bit of warmth to the image, so I'll leave just a hint of it in.One of my earliest memories of running into this photographic issue was back in 2003. If the values are to the right of the histogram, your picture will appear more yellow. All I need to do at this point to remove the color cast is drag the Density slider to the right, which will determine how much of my inverted color is being blended into the image, until my image looks better. Step 4: Drag The Density Slider To Remove The Color Castīack in the Photo Filter dialog box, I can see that the color swatch is now showing my inverted color. I can now use this color to neutralize my color cast.Ĭlick OK when you're done to exit out of the Color Picker. We can see in the Color Picker above that my color has now changed to more of a blue color, and that is the opposite of the orange color I sampled. So add a negative sign if there isn't one, and remove it if there is one to invert the color. If you already had a negative sign in your "a" or "b" values, simply remove it. Add a negative ("-") sign in front of the "a" and "b" values to invert the color. Localising your app could help reach an additional 40% of the world! * Export One design, export all the screenshots required by the app store, which is fast and easy to use. * Translate Translate, localize and export your screenshots for more countries. You can even preview the screenshot before chooing any of the 960 Google fonts. * Font Picker Choosing a perfect font with the new stunning Font Picker is a pleasure. * Title & Subtitle With more options than ever, update the Title and Subtitle to match your design goals. * Background Set your background to a solid color, gradient, image or even a panoramic, like we showed you. Use stunning 3D phone mockups to show your app in context and add a layer of polish to help your app stand out from the rest. * Layouts There are more than 30 different layout templates you can choose from, with more being added every time. Editing/displaying 3D video in Stereo Photo Maker (SPM) Auto. Resize, rotate and position the device anywhere in the screenshot. Fixed a problem that iPhone screenshot PNGs (3-channel 16-bit) cannot be displayed correctly. * Devices Choose real devices, solid color or clay frames. Transparent background (will reload) Post processing Vignette Camera position Import Export. * Store Preview See how your screenshots will look on the App Store and Play Store for every device. Resolution × (4096 max) Export screenshot. Update device frames, layouts, gradients, title and subtitle at the click of a button. App Mockup has templates for every type of app. Functions: * Templates Bring your app screenshots to life faster than ever. Short on time? Muddling through Sketch, Photoshop or mockup generators? Not sure which screenshot sizes you need? Looking for an easier way? You have just found App Mockup. All exported in high resolution PNG images on demand, ready for upload. We are the only tool who provide localization, panoramic backgrounds, 3D devices, rich text with emojis and much more. The progress bar below the 3D box image indicates the optimal rendering time. ![]() ![]() It may take some time for the noise to come away and you get a nice and clear picture. Every time you move the camera or change a parameter the rendering starts from the beginning. From a single responsive design, App Mockup exports all required screenshot sizes for apps on the Apple App & Google Play Store (including iPhone, iPad, Android phones & tablets). This page is constantly rendering a 3D box mockup with the artwork you loaded. We simplify the process of designing and generating professional screenshots for iOS and Android apps simultaneously. App Mockup is the easiest to use screenshot creator, a dedicated screenshot mockup generator. ![]() With a eclectic group ranging from country legends like Cash and Kristofferson to 60's cronies like The Band and Eric Clapton to underground idols like Lou Reed and (then) current superstars like Pearl Jam showcase just what type of long-lasting impact Dylan had, and still does. ![]() The performers, well known and not as well known, obviously have an affection for Bob, his person and his music, and it shows. I got to speak to Richie Havens after his show, one of the sweetest and most genuine guys I've ever met, and discussed his performance here with him. I put them both on my personal "must see live" list and ultimately did catch them both in concert at various times. There's a lot of hit and miss but I wanna say in particular two performances that hit me like a ton of curly Jewish hair: Johnny Winter's slide guitar guided barnstorm of "Highway 61 Revisited" and Richie Havens' sublime "Just Like a Woman." Of all the performances, they stuck with me the most and had me looking at them as more than their Woodstock images I had embedded in my brain. Just for the record, I still have both the laserdisc player and all my laserdiscs I ended up purchasing including the Star Wars trilogy, this Dylan tribute and even Don't Look Back. Anyhow despite some big names that don't make it, and some faults by some who do, I really enjoyed the concert, then and now. So I could watch this tribute concert from 1992. So I could watch the ORIGINAL versions of the Star Wars films and 2. Once upon a time I hunted the world over for a laserdisc player (remember those kids?) for two simple reasons: 1. Personal Bias/Quasi-Film Review: Once upon a time, you dressed so fine, you.nevermind. ![]() Added bonus: many of these clever crafts double as handmade Christmas gift ideas for your loved ones. Beautiful Christmas Scene stock photos are available in a variety of sizes and formats to fit your needs. All pictures and Christmas wallpapers for mobile are free of charge. ![]() Decorations on christmas tree - Download Free Stock Photos Pikwizard. Your preschooler will love the tea light snowman ornament, while older kids will have a blast cutting paper snowflakes. Browse Getty Images premium collection of high-quality, authentic Beautiful Christmas Scene stock photos, royalty-free images, and pictures. You can download any Christmas mobile wallpaper for phone. Aesthetic Pictures American Flag Angel Animal Wildlife Autumn Baby Background. ![]() Whether you have toddlers or school-age children, we've sprinkled in a ton of easy Christmas crafts that you can make with your kids. To help you stay on budget and take better care of the environment, we've found plenty of upcycling ideas that use what you've got at home (like old lightbulbs, lip balm containers or glass jars). Free After the Silence Photo for Download Related pictures featuring landscape, panorama & more. Find instructions and links to step-by-step tutorials for fun projects, like an air dry Christmas village, popsicle stick wreaths, candy cane pillows and felt gnomes. No matter your aesthetic or skill level, we've included a mix of traditional, modern and whimsical craft ideas - so you can find something that sparks that Christmas joy. Free download free beautiful christmas images photos 6,383 files in. winter christmas snow mountain snowing snowflake ice nature mountain rain christmas background snowman christmas lights fall forest snow city sea. Christmas Sidewalk Roads Lights White Trees Desktop Images 1920x1200px brown. Thousands of new images every day Completely Free to Use High-quality videos and. christmas landscape 1080P, 2K, 4K, 5K HD wallpapers free download, these. Dreamstime is the worlds largest stock photography community. Download and use 50,000+ Snow stock photos for free. Thousands of new images every day Completely Free to Use High-quality videos and images from Pexels. Picture this: a beautiful living room with hand-stitched stockings, a Christmas tree adorned with DIY ornaments and a front door decorated with homemade wreaths. Use them in commercial designs under lifetime, perpetual & worldwide rights. Download and use 60,000+ Winter Scenes stock photos for free. Whether you consider yourself a skilled crafter or more of a beginner, we've rounded up Christmas crafting ideas that will inspire you to break out the hot glue gun. When the Christmas season rolls around, there's nothing like getting into the holiday spirit by decorating the entire house, whipping up festive recipes and experimenting with a slew of Christmas crafts. Therefore, there is a need for a new integrin therapeutic modality with (i) high selectivity for a single RGD integrin heterodimer, (ii) atomic-level control over the precise location of the target binding site and the protein-protein interaction interfaces to control the evoked integrin conformation, (iii) hyperstability to enable tissue restricted administration (inhaled and oral), and (iv) a smaller hydrodynamic size than IgG antibodies to enable better tissue penetration. Since eight integrin heterodimers, including αvβ6 and αvβ8, share the conserved RGD binding sequence, it has not been possible to generate selective RGD-mimetic small molecules for individual integrins, making it challenging to dissect the role a single integrin plays in a particular disease 23. For example, the mAb BG00011 and small molecule MORF-720 both target the non-internalized, bent-closed αvβ6 conformation 11, 15 and have on-target/αvβ6-mediated toxicity 17, 18, 19, while the small molecules PLN-74809 20 and GSK3008348 21 stabilize the extended-open αvβ6 conformation that induces αvβ6 internalization, and have not shown any drug-related serious adverse events in clinical trials 22. Control over the target site is important because differential modulation of αvβ6 integrin conformations (bent-closed, extended-closed, and extended-open) by orthosteric and allosteric inhibitors has dramatically different outcomes on receptor internalization 11, 14, 15 and has been linked to safety outcomes in preclinical and clinical studies 16. Selective antibodies targeting RGD integrins have been generated by immunizing mice 11, 12, 13, but this approach lacks precise control over the target binding site on the integrin. ![]() Upregulation of αvβ6- and/or αvβ8-mediated TGF-β activation is a driver of multiple diseases, including idiopathic pulmonary fibrosis (IPF) 4, 5, 6, primary sclerosing cholangitis (PSC) 7, and several solid tumors 8, 9, 10, but deconvoluting the contribution of αvβ6 and αvβ8 to the etiology of these diseases has been challenging due to limitations in current interventions. The highly homologous integrins αvβ6 and αvβ8 bind to latent transforming growth factor-β1 and β3 (L-TGF-β1 and L-TGF-β3) leading to release of active TGF-β1 and -β3 1, 2, 3. In a lung fibrosis mouse model, the αvβ6 inhibitor potently reduced fibrotic burden and improved overall lung mechanics, demonstrating the therapeutic potential of de novo designed integrin binding proteins with high selectivity. CryoEM structures of the designed inhibitor-integrin complexes are very close to the computational design models, and show that the inhibitors stabilize specific conformational states of the αvβ6 and the αvβ8 integrins. We design hyperstable, selective αvβ6 and αvβ8 inhibitors that bind with picomolar affinity. Here we describe a generalized method for computationally designing RGD-containing miniproteins selective for a single RGD integrin heterodimer and conformational state. Existing small molecule and antibody inhibitors do not have all these properties, and hence new approaches are needed. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integrins, stabilize specific conformational states, and have high thermal stability could have considerable therapeutic utility. The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Nature Communications volume 14, Article number: 5660 ( 2023) De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8 |
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